Dr. S. ASHOK KUMAR

Research interests

Clinical studies and Metabolic disorder

Research Guidance

Guided

• No. of PhD students (Completed) – 2

• No. of MS (by Research) students (Completed) – 2

• No of PhD Students (Pursuing) - 1

• No. of M. Tech students guided - 25

Students completed Ph. D. under my Guidance

Name of the Scholar	Title of the Thesis	Date of Viva- Voce
Ms. V. Helen Shiphrah	Evaluation of Apoptotic Activity of Acid Ceramidase Inhibitor, Ceranib 2 in Human Breast Cancer Cell Lines	03/11/2017
Ms. P. Vishnu Priya	Deep sea bacterial diversity and bioprospecting potentials of peizotolerant Streptomyces species	14/06/2018

Students completed MS (by Research) under my Guidance

Name of the Scholar	Title of the Thesis	Date of Viva- Voce
Mr. Ganesh Babu	Role of hydrogen sulphide and nitric oxide in oxidized LDL treated endothelial cells	26/12/2016
Ms.Sivapriya S	Study on identification of biomarkers for Age related macular degeneration	26/12/2016

Publications

• Loganathan C, Kannan A, Panneerselvam A, Mariajoseph-Antony LF, Kumar SA, Anbarasu K, Prahalathan C. The possible role of sirtuins in male reproduction. Mol Cell Biochem. 2021 Mar 18. doi: 10.1007/s11010-021-04116-2.
• Sivagurunathan S, Selvan LDN, Khan AA, Parameswaran S, Bhattacharjee H, Gogoi K, Gowda H, Keshava Prasad TS, Pandey A, Kumar SA, Rishi P, Rishi E, Ratra D, Bhende M, Janakiraman N, Biswas J, Krishnakumar S. Proteomics‑based approach for differentiation of age‑related macular degeneration sub‑types. Indian J Ophthalmol. 2021;69(3):647-654.
• HS Vethakanraj, N Chandrasekaran, AK Sekar. Acid ceramidase, a double-edged sword in cancer aggression: A minireview. Current Cancer Drug Targets 2020 Dec DOI : 10.2174/1568009620666201223154621
• Vishnu Priya Padmanaban, Pankaj Verma, Dharani Gopal, Ashok Kumar Sekar, Kirubagaran Ramalingam. Phylogenetic identification and metabolic potential of bacteria isolated from deep sea sediments of Bay of Bengal and Andaman Sea. Indian Journal of Experimental Biology Vol. 57, August 2019, pp. 561-572
• Rajendran P, Alzahrani AM, Hanieh HN, Kumar SA, Ben Ammar R, Rengarajan T, Alhoot MA. Autophagy and senescence: A new insight in selected human diseases. J Cell Physiol. 2019 Dec;234(12):21485-21492.
• Vethakanraj HS, Sesurajan BP, Padmanaban VP, Jayaprakasam M, Murali S,Sekar AK.Anticancer effect of acid ceramidase inhibitor ceranib-2 in humanbreast cancer cell lines MCF-7, MDA MB-231 by the activation of SAPK/JNK, p38 MAPK apoptotic pathways, inhibition of the Akt pathway, down regulation of ERα. Anticancer Drugs. 2018 Jan;29(1):50-60.
• Helen Shiphrah Vethakanraj, and Sekar Ashok Kumar. Evaluation of Synergistic effect of Ceranib 2 and Tamoxifen in human breast cancer cells. Research Journal of Pharmaceutical, Biological and Chemical Sciences. 2017:8(4): 1110-1114.
• Padmanaban VP, Verma P, Venkatabaskaran S, Keppayan T, Gopal D, SekarAK, Ramalingam K. Antimicrobial potential and taxonomic investigation of piezotolerant Streptomyces sp. NIOT-Ch-40 isolated from deep-sea sediment.World J Microbiol Biotechnol. 2017 Feb;33(2):27.
• Babu Thabraz Ahmed and Sekar Ashok Kumar. Antioxidant and Antidiabetic properties of Abelmoschus esculentus extract – an in vitro assay. Res. J. Biotech. Vol. 11 (3) March (2016) 34-41
• Vethakanraj HS, Babu TA, Sudarsanan GB, Duraisamy PK, Kumar SA.Targeting ceramide metabolic pathway induces apoptosis in human breast cancer cell lines. Biochem Biophys Res Commun. 2015 Aug 28;464(3):833-9.
• Kumar SA, Hu X, Brown M, Kuschak B, Hernandez TA, Johnston JB, GibsonSB. Lysophosphatidic acid receptor expression in chronic lymphocytic leukemia leads to cell survival mediated though vascular endothelial growth factor expression. Leuk Lymphoma. 2009 Dec;50(12):2038-48.
• Sudhahar V, Ashok Kumar S, Varalakshmi P, Sujatha V. Protective effect of lupeol and lupeol linoleate in hypercholesterolemia associated renal damage. Mol Cell Biochem. 2008 Oct;317(1-2):11-20.
• Sudhahar V, Kumar SA, Varalakshmi P, Sundarapandiyan R. Mitigating role of lupeol and lupeol linoleate on hepatic lipemic-oxidative injury and lipoprotein peroxidation in experimental hypercholesterolemia. Mol Cell Biochem.2007;295:189-98.
• Sudhahar V, Kumar SA, Sudharsan PT, Varalakshmi P. Protective effect of lupeol and its ester derivative on cardiac abnormalities in experimental hypercholesterolemia. Vasc Pharmacol. 2007;46:412-8.
• Kumar SA, Sudhahar V, Varalakshmi P. Protective role of eicosapentaenoatelipoate(EPA-LA) derivative in combating oxidative hepatocellular injury in hypercholesterolemic atherogenesis. Atherosclerosis 2006;189:115-22.
• Kumar SA, Sudhahar V, Varalakshmi P. Oxidative renal injury and lipoprotein oxidation in hypercholesterolemic atherogenesis: Role of eicosapentaenoatelipoate (EPA-LA) derivative. Prostaglandins Leukot Essent Fatty Acids.2006;75:25-31.
• Sudhahar V, Kumar SA, Varalakshmi P. Role of lupeol and lupeol linoleate on lipemic-oxidative stress in experimental hypercholesterolemia. Life Sci. 2006; 78:1329-35.
• Sudhahar V, Ashokkumar S, Varalakshmi P. Effect of lupeol and lupeol linoleate on lipemic--hepatocellular aberrations in rats fed a high cholesterol diet. Mol Nutr Food Res. 2006;50:1212-9.
• Kumar SA, Sudhahar V, Varalakshmi P. Attenuation of serum lipid abnormalities and cardiac oxidative stress by Eicosapentaenoate-lipoate (EPA-LA) derivative in experimental hypercholesterolemia. Clinica Chimica Acta 2005; 355: 197-204.

Awards and Honors

• Received CancerCare Post Doctoral Research fellow award (15th rank out of 31 Applications) from Manitoba Health Research Council (MHRC), Winnipeg, Manitoba,Canada (July 2008- June 2009).
• Qualified in Council of Scientific and Industrial Research-Junior Research Fellowship and National Eligibility Test for Lectureship (CSIR-UGC JRF and NET) examination held on December, 2001.

Board of Studies & Curriculam Design

• Member of Board of Studies in Biotechnology, PSG College of Arts and Science, Coimbatore affiliated to Bharathiar University (2011-2013).
• Coordinator for preparing (CBCS) Curriculum and Syllabus for M. Tech. Food Technology (Regulation-2015), Anna University.

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