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DBT, Govt. of India Supported Project "Structural Informatics and Chemical Biology-BIC"

Structural Informatics and Chemical Biology-BIC at Department of Biotechnology, Anna University, Chennai


Supported by DBT, Govt.of India

Principal Investigator : Dr.B.S.Lakshmi, Professor, Department of Biotechnology, Anna University, Chennai

The Anna University Bioinformatics Centre (AU-BIC) focuses on development of research and manpower in the thematic areas of Structural Informatics and Chemical Biology. With the Centers enhanced infrastructure facility and manpower, the Centre aims to achieve an unique identity as a potential and leading BIC with expertise in Structural Informatics and Chemical Biology.The Center has Two Servers, Seven Molecular Graphics workstations and Drug design software to provide research facilities to facilitate research in structural informatics and chemical biology and to provide education and training services in bioinformatics and computational biology.

BICLab1

BIC Lab1

BICLab2

BIC Lab2

BICLab2

BIC Lab1


Research

  • Contributes to research in the thematic area of structural informatics and chemical biology.

  • In silico investigations on the binding efficacy and allosteric mechanism of six different natural product compounds towards PTP1B inhibition through docking and molecular dynamics simulations

  • Identification of potential lead candidates for diabesity targets, Protein-Protein interactions

  • Determine the efficacy of the herbal isolates or plant products, as well as drug repurposing against the identified candidate regulator genes involved in diabesity

  • In-silico studies of Crystallin proteins, Plant proteins, Plant defensins, In-silico studies of neurodegenerative diseases.

  • Research on Neuro-cognitive herbal isolates or drug repurposing to target the regulator proteins involved in neurodegenerative diseases like Alzheimer’s for understanding disease mechanisms.

    • BIC Project Principal Investigator

    BIC Workshop

    A workshop titled "Workshop on Chemoinformatics for Drug Discovery" was conducted from March 15–18, 2023, for college teachers and research scholars. The Workshop aims to introduce College Teachers and Researchers to the field of cheminformatics. Twenty Teaching Professionals and Research Scholars participated and attended all lectures and hands on sessions enthusiastically. Lectures, Demos and hands on Sessions on Chemoinformatics, Structure based Drug Discovery, Machine learning for Drug Discovery, Small Molecule Databases and Structural Databases, Homology Modelling, Molecular Docking, Molecular Dynamics Simulation and Ligand based Drug Discovery were given by Eminent Professors and Scirntists.

    WS1

    Inauguration

    WS2

    Lecture

    WS3

    Lecture

    WS4

    Valedictory

    WS5

    Valedictory

    WS6

    Valedictory

    Publications

  • Madanagopal P, Muthukumar H, Thiruvengadam Kothai (2022). Computational study and design of effective siRNAs to silence structural proteins associated genes of Indian SARS-CoV-2 strains. ComputBiol Chem. 98:107687

  • Ramaswamy K, Rashid M, Ramasamy S, Jayavelu T, Venkataraman S (2022). Revisiting Viral RNA-Dependent RNA Polymerases: Insights from Recent Structural Studies. Viruses.14 (10):2200.